1838 - Founding of Cambridge's first public high School in Cambridgeport at the corner of Broadway and Windsor streets.

1848 - Construction of a unified Cambridge High School (CHS) a the corner of Amory and Summer streets.  CHS incorporated the former Cambridgeport, Otis and Female High Schools.

1886 - Establishment of the Cambridge Latin School (CLS), with classes reportedly held at the private residence of one of its teachers.

1888 - Founding of the Cambridge Manual Training School for Boys, later to become Rindge Technical School.

1892 - Construction of the Cambridge English High School (CEHS) building on Trowbridge Street between Cambridge and Broadway.  The Cambridge Latin School then continued its operation at the former CHS building on Fayette Street.

1898 - Cambridge Latin School moved to its permanent location in a new building constructed on Trowbridge Street on the Cambridge Street side of CEHS

(Year uncertain) - Construction of the Rindge Technical School building to the west of CLS and CEHS

1910 - Merger of CLS and CEHS into a new unified school known as the Cambridge High and Latin School. The two buildings were then or shortly after interconnected.

1978 - Merger of the Cambridge High and Latin School and the Rindge Technical School into The Cambridge Rindge Latin School (CRLS)

1978 to 1980 – Use of the CHLS building is phased out preparatory to closure.

1980 - Closure and demolition of the Cambridge High and Latin School.  Classes continue in the Rindge Technical School building and in new, contiguous construction.  Some historical items from CLS and CHLS, such as antique cabinets, are put in use in the new facilities.  The granite lintel and main front door frame of the CHLS building, through which every CLS and CHLS student passed for decades,  is preserved and set up at the corner of Ellery and Broadway streets as an entry portal to Lorentz Park.

2007 - Further improvement at the site of CRLS is planned, and later begun by 2008.